Open Essex

Canine (Dog) Monoclonal Antibody Discovery

In recent years, dogs have emerged as a powerful and underutilized host species for monoclonal antibody discovery, particularly when it comes to generating antibodies against canine-relevant antigens, large proteins, and complex conformational structures.

The diverse immune repertoire and robust antibody responses of dogs make them particularly valuable for generating antibodies that are challenging to obtain from traditional models such as mice or rabbits.

Our core canine antibody discovery services include:

Custom antigen design, peptide synthesis, and protein engineering
Tailored canine immunization protocols
Immune, naïve, or synthetic phage display library construction using canine-derived sequences
High-throughput phage display library screening
Clone validation with binding and specificity assays
Recombinant antibody expression and purification
Optional Fc engineering and isotype switching
in vivo validation support (if needed)