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ADME is short for "absorption, distribution, metabolism, and excretion." The four properties determine the drug exposure to tissues, the drug level within a body. Also, a compound's metabolic process can help predict the bioactivity and bioavailability of a drug. Therefore, understanding the ADME properties of a compound is essential to drug development.

Creative Bioarray provides a variety of in vitro ADME/PK services, including high-throughput ADME screening, in vitro binding, in vitro metabolism, in vitro permeability, and transporter assays.

Drug absorption is drugs' movement  into the bloodstream. This process is influenced by many factors, including drugs formulation, physicochemical properties, and route of administration. Regardless of the route of administration, the drug must first be dissolved and absorbed before it can exert a therapeutic effect. By intervening in factors that affect drug absorption, its pharmacokinetic (PK) characteristics can be changed.

Drugs' permeability across biological membranes is a critical factor that influences the absorption and distribution. Drugs may cross cell membranes through passive diffusion, facilitated passive diffusion, active transport, and pinocytosis. The drug's physicochemical properties (such as lipophilicity and molecular size), and membrane-based efflux, can lead to poor permeability.