aquatic life-based research

Inflammatory and immune-mediated diseases represent a growing and complex challenge in veterinary medicine, affecting the quality of life for countless dogs and cats. Conditions like atopic dermatitis, inflammatory bowel disease (IBD), and immune-mediated arthritis are often chronic and debilitating. As the need for safer and more effective therapies escalates, biotech and pharmaceutical companies require a dedicated research partner to navigate the path to approval with expertise and efficiency.

Target Identification & Validation

  • Cytokine, chemokine, and inflammatory mediator profiling.
  • Utilization of genomics, transcriptomics, and proteomics to identify novel targets and biomarkers and pathways in canine and feline disease states.
  • In vitro and ex vivo functional assays to validate novel immune targets.

In Vitro Immunology & Inflammation Assays

  • Immune cell proliferation, activation, and differentiation studies.
  • Cell-based assays for inflammation.
  • Mixed Lymphocyte Reaction (MLR) and other cellular immunogenicity assays.
  • Customized co-culture systems and barrier function models.
(Creative Biolabs Authorized)

In Vivo Disease Models

  • Spontaneous disease models that reflect naturally occurring conditions.
  • Induced models of acute and chronic inflammation for mechanism-of-action studies.
  • Canine and feline models of osteoarthritis and other immune-mediated joint diseases.
  • Immunocompetent systems to evaluate immunomodulatory agents and biologics.

Preclinical Efficacy & Safety Evaluation

  • Pharmacokinetics (PK) and pharmacodynamics (PD) studies with key biomarker readouts.
  • Dose-range finding and therapeutic efficacy testing.
  • Comprehensive safety and tolerability assessments.
  • Immunotoxicology and evaluation of anti-drug antibodies (ADA).
Workflow Description
Strategic Project Planning We begin with an in-depth consultation to understand your scientific hypothesis, target product profile, and key research objectives.
Tailored Study Design Our scientific team collaborates with you to develop a robust, customized protocol that is scientifically sound and aligned with your program milestones.
Flawless Execution & Proactive Communication A dedicated project manager oversees all study activities, providing regular progress updates and ensuring adherence to timelines and quality standards.
Data Analysis & Reporting Upon study completion, we provide a comprehensive report featuring high-quality data, detailed statistical analysis, and expert interpretation to empower your program's critical next steps.
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